Services

Sable Systems International Promethion metabolic cages provide high resolution measures with industry leading accuracy of respirometry and behavior. 

Housing temperature significantly influences energy and glucose homeostasis in the mouse. For mice, thermoneutrality (approximately 30°C) represents the temperature at which no additional energy must be expended beyond basal metabolic rate to maintain euthermia. 

Quantify body composition accurately and efficiently using our EchoMRI.

Oxygen bomb calorimetry is the gold standard for measurement of caloric content. Coupled with assessment of 24-hour food intake, calorimetric determination of calories excreted accurately quantifies nutrient absorption. Together with body mass, activity and energy expenditure measurements, this analysis allows mechanistic insight into the regulation of energy balance in the mouse.

Determine thermogenic tissue function or core body temperature using infrared thermography.

Glucose metabolism in mice can be assessed using a panel of standalone in vivo tests or coupled with metabolic cage or environmental housing experiments. Assessing glucose and insulin levels in the blood in response to a variety of stimuli enables a broader metabolic characterization of your mouse.

The Agilent Seahorse XFe24 Analyzers measure the oxygen consumption rate (OCR) and extracellular acidification rate (ECAR) of live cells in a 24-well plate format. The OCR and ECAR provide insight into the cellular metabolic function of cultured cells and ex-vivo samples by indicating mitochondrial respiration and glycolysis, as well as ATP production rate. 

Agilent's Seahorse XFe96 Analyzer measures the oxygen consumption rate (OCR) and extracellular acidification rate (ECAR) in cultured cells and isolated mitochondria in a 96-well plate format. The assessment of OCR and ECAR are key indicators of mitochondrial respiration and glycolysis and these measurements provide a systems-level view of cellular metabolic function.