Metabolic Phenotyping Center

Services

Metabolic Cages

Sable Systems International Promethion metabolic cages provide high resolution measures with industry leading accuracy of respirometry and behaviour. 

Environmental Housing

Housing temperature significantly influences energy and glucose homeostasis in the mouse. For mice, thermoneutrality (approximately 30°C) represents the temperatre at which no additional energy must be expended beyond basal metabolic rate to maintain euthermia. 

Body Composition

Quantify body composition accurately and efficienty using our EchoMRI.

Bomb Calorimetry

Oxygen bomb calorimetry is the gold standard for measurement of caloric content. Coupled with assessment of 24-hour food intake, calorimetric determination of calories excreted accurately quantifies nutrient absorption. Together with body mass, activity and energy expenditure measurements, this analysis allows mechanistic insight into the regulation of energy balance in the mouse.

Infrared Thermography

Determine thermogenic tissue function or core body temperature using infrared thermography.

Glucose Metabolism

Glucose metabolism in mice can be assessed using a panel of standalone in vivo tests or coupled with metabolic cage or environmental housing experiments. Assessing glucose and insulin levels in the blood in response to a variety of stimuli enables a broader metabolic characterization of your mouse.

Seahorse Analyzer XFe 24

The Agilent Seahorse XFe24 Analyzers measure the oxygen consumption rate (OCR) and extracellular acidification rate (ECAR) of live cells in a 24-well plate format. The OCR and ECAR provide insight into the cellular metabolic function of cultured cells and ex-vivo samples by indicating mitochondrial respiration and glycolysis, as well as ATP production rate. 

Seahorse Analyzer XFe 96

Agilent's Seahorse XFe96 Analyzer measures the oxygen consumption rate (OCR) and extracellular acidification rate (ECAR) in cultured cells and isolated mitochondria in a 96-well plate format. The assessment of OCR and ECAR are key indicators of mitochondrial respiration and glycolysis and these measurements provide a systems-level view of cellular metabolic function.

Contact Us

Interested in our equipment but not sure where to start? Reach out to us here, and we will coordinate a consultation visit. 

Acknowledgement Pledge

We require all core clients acknowledge the Metabolic Phenotyping Center of Weill Cornell Medicine in publications and presentations enabled by the use of our resources.

Schedule An Experiment

MPC Logo

Ready to schedule an experiment? Head on over to our iLabs service page and submit an experiment request, or shoot us an email. We'll help plan your metabolic cage experiment and suggest the use of our other core tools to best phenotype your mouse.

Email Us

Weill Cornell Medicine
Metabolic Phenotyping Center 413 E. 69th St. Room BB-650 New York, NY 10021 Phone: 646-962-6745