Metabolic Cages

Sable Systems International Promethion metabolic cages provide high resolution measures with industry leading accuracy of respirometry and behavior. 

metabolic cage
  • 3 Promethion High-Definition Multiplexed Respirometry Systems for mice, each with 8 cages, allow for simultaneous monitoring of 24 mice.
  • Each Promethion system is located within an ambient temperature- and light- controlled environmental enclosure DB034-LT Laboratory Incubator, Darwin Chambers Company, St Louis, MO allowing precise temperature control between 4 °C and 34 °C.
  • Indirect calorimetry, the in vivo measurement of both oxygen consumption and carbon dioxide production, is assessed per mouse a minimum of 12 times per hour (in 5 minute intervals). With this information we can determine the respiratory exchange ratio and energy expenditure with a high temporal resolution.
  • Food intake, water intake, and body mass are assessed continuously using in-cage balances.
  • Activity is assessed using a 2D laser matrix with 1 cm spatial resolution. Distance traveled and total movement are calculated from bream breaks.
  • Injections, removal of food and other manipulations can be performed during monitoring with minimal interruptions in data collection. 

Optional Features:

  • A running wheel can be installed within each cage to measure voluntary activity.
  • Core body temperature and heart rate can be monitored continuously following surgical implantation of the G2 E-Mitter or G2 Heart Rate E-Mitter.
  • Fully enclosed bio-exclusive Techniplast ISO-P Cages fitted with HEPA filters allow metabolic monitoring of gnotobiotic, germ-free or immunocompromised animals.
    • Cage design does not allow for continuous assessments of food intake, water intake, body mass or voluntary activity (running wheel).
Weill Cornell Medicine Metabolic Phenotyping Center
413 E. 69th St.
Room BB-660
New York, NY 10312
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