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Dissociation of Adaptive Thermogenesis from Glucose Homeostasis in Microbiome-Deficient Mice.

TitleDissociation of Adaptive Thermogenesis from Glucose Homeostasis in Microbiome-Deficient Mice.
Publication TypeJournal Article
Year of Publication2020
AuthorsKrisko TI, Nicholls HT, Bare CJ, Holman CD, Putzel GG, Jansen RS, Sun N, Rhee KY, Banks AS, Cohen DE
JournalCell Metab
Volume31
Issue3
Pagination592-604.e9
Date Published2020 03 03
ISSN1932-7420
Abstract

Recent studies suggest that a key mechanism whereby the gut microbiome influences energy balance and glucose homeostasis is through the recruitment of brown and beige adipocytes, primary mediators of the adaptive thermogenic response. To test this, we assessed energy expenditure and glucose metabolism in two complementary mouse models of gut microbial deficiency, which were exposed to a broad range of thermal and dietary stresses. Neither ablation of the gut microbiome, nor the substantial microbial perturbations induced by cold ambient temperatures, influenced energy expenditure during cold exposure or high-fat feeding. Nevertheless, we demonstrated a critical role for gut microbial metabolism in maintaining euglycemia through the production of amino acid metabolites that optimized hepatic TCA (tricarboxylic acid) cycle fluxes in support of gluconeogenesis. These results distinguish the dispensability of the gut microbiome for the regulation of energy expenditure from its critical contribution to the maintenance of glucose homeostasis.

DOI10.1016/j.cmet.2020.01.012
Alternate JournalCell Metab
PubMed ID32084379
Grant ListR01 DK103046 / DK / NIDDK NIH HHS / United States
R01 DK107717 / DK / NIDDK NIH HHS / United States
T32 DK007533 / DK / NIDDK NIH HHS / United States
P30 DK034854 / DK / NIDDK NIH HHS / United States
S10 OD020100 / OD / NIH HHS / United States