Title | Nutritional Support from the Intestinal Microbiota Improves Hematopoietic Reconstitution after Bone Marrow Transplantation in Mice. |
Publication Type | Journal Article |
Year of Publication | 2018 |
Authors | Staffas A, da Silva MBurgos, Slingerland AE, Lazrak A, Bare CJ, Holman CD, Docampo MD, Shono Y, Durham B, Pickard AJ, Cross JR, Stein-Thoeringer C, Velardi E, Tsai JJ, Jahn L, Jay H, Lieberman S, Smith OM, Pamer EG, Peled JU, Cohen DE, Jenq RR, van den Brink MRM |
Journal | Cell Host Microbe |
Volume | 23 |
Issue | 4 |
Pagination | 447-457.e4 |
Date Published | 2018 04 11 |
ISSN | 1934-6069 |
Abstract | Bone marrow transplantation (BMT) offers curative potential for patients with high-risk hematologic malignancies, but the post-transplantation period is characterized by profound immunodeficiency. Recent studies indicate that the intestinal microbiota not only regulates mucosal immunity, but canĀ also contribute to systemic immunity and hematopoiesis. Using antibiotic-mediated microbiota depletion in a syngeneic BMT mouse model, here we describe a role for the intestinal flora in hematopoietic recovery after BMT. Depletion of the intestinal microbiota resulted in impaired recovery of lymphocyte and neutrophil counts, while recovery of the hematopoietic stem and progenitor compartments and the erythroid lineage were largely unaffected. Depletion of the intestinal microbiota also reduced dietary energy uptake and visceral fat stores. Caloric supplementation through sucrose in the drinking water improved post-BMT hematopoietic recovery in mice with a depleted intestinal flora. Taken together, we show that the intestinal microbiota contribute to post-BMT hematopoietic reconstitution in mice through improved dietary energy uptake. |
DOI | 10.1016/j.chom.2018.03.002 |
Alternate Journal | Cell Host Microbe |
PubMed ID | 29576480 |
PubMed Central ID | PMC5897172 |
Grant List | R01 AI101406 / AI / NIAID NIH HHS / United States P30 CA016672 / CA / NCI NIH HHS / United States R01 HL069929 / HL / NHLBI NIH HHS / United States R01 DK056626 / DK / NIDDK NIH HHS / United States P01 CA023766 / CA / NCI NIH HHS / United States R01 HL124112 / HL / NHLBI NIH HHS / United States R01 DK103046 / DK / NIDDK NIH HHS / United States R01 AI080455 / AI / NIAID NIH HHS / United States R29 DK048873 / DK / NIDDK NIH HHS / United States P30 CA008748 / CA / NCI NIH HHS / United States R37 DK048873 / DK / NIDDK NIH HHS / United States R01 DK048873 / DK / NIDDK NIH HHS / United States R01 AI100288 / AI / NIAID NIH HHS / United States |